Article ID Journal Published Year Pages File Type
10797264 Biochimica et Biophysica Acta (BBA) - Biomembranes 2012 8 Pages PDF
Abstract
► MPER is a membrane-transferring domain implied in the fusogenic activity of HIV gp41. ► The molecular mechanism underlying its membrane activity remains to be elucidated. ► We have studied this mechanism by X-ray scattering techniques in peptide-lipid monolayers. ► Our results support the idea that the hydrophobic insertion of MPER domain generates curvature within the viral membrane.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Mechanism of membrane perturbation by the HIV-1 gp41 membrane-proximal external region and its modulation by cholesterol
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