| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797290 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 7 Pages |
Abstract
⺠The interaction between Bax and mitochondrial membranes are investigated. ⺠Oxidative stress conditions are mimicked by using the OxPl PazePC. ⺠Presence of PazePC enhances Bax association with the membranes. ⺠We propose OxPls can increase the population of membrane-associated Bax in vivo. ⺠The distorted bilayer organization presumably facilitates insertion of the protein.
Keywords
PoPC1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholineOxPLsPazePCMLVsTMCLDSCMAS NMRnuclear magnetic resonance1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholinemitochondrial outer membrane permeabilizationROSSUVsmultilamellar vesiclesimmBaxMASNMRApoptosisinner mitochondrial membraneMelting Temperaturecircular dichroismmagic angle spinningmitochondrial outer membranephosphatidylcholineoxidized phospholipidsMoMMOMPPOPECardiolipinDifferential scanning calorimetrysmall unilamellar vesiclesReactive oxygen species
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Authors
Marcus Wallgren, Martin Lidman, Quoc Dat Pham, Konrad Cyprych, Gerhard Gröbner,