| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797307 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 13 Pages |
Abstract
⺠We have studied the membranotropic regions of DENGUE NS4A and NS4B proteins. ⺠NA4A displayed three membrane-interacting regions, possibly transmembrane domains. ⺠NS4B showed nine membranotropic regions, both transmembrane and interacting domains. ⺠These zones should be involved in the formation of the replication complex.
Keywords
EPAegg l-α-phosphatidic acidbovine brain l-α-phosphatidylserinebovine heart cardiolipin1,2-dielaidoyl-sn-glycero-3-phosphatidylethanolamine5-CarboxyfluoresceinDEPEDPHTFEMLVDENVBPIBPSDSCCHOLdMPCEPCESMTPE1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine1,6-diphenyl-1,3,5-hexatriene2,2,2-trifluoroethanolmultilamellar vesiclesegg sphingomyelinepglarge unilamellar vesiclesegg l-α-phosphatidylcholineLipid–peptide interactiontransmembrane domainendoplasmic reticulumLemLUVBMPHepatitis C virusHCVmembranous webDengue virusNon-structural proteinReplication complexDifferential scanning calorimetrycholesterol
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Authors
Henrique Nemésio, Francis Palomares-Jerez, José VillalaÃn,