| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797316 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 8 Pages |
Abstract
⺠Monomeric alpha-synuclein causes bursts of conductance in Planar Lipid Membranes. ⺠Three levels of sequentially related conductance levels were identified. ⺠Covalently bound alpha-synuclein dimers allow to explore relative orientation of the monomers in the pore. ⺠Alpha-synuclein forms barrel stave pores with the progressive insertion of four helical units. ⺠A model of pore formation accounting for the conductance levels is proposed.
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Authors
Laura Tosatto, Alberto O. Andrighetti, Nicoletta Plotegher, Valeria Antonini, Isabella Tessari, Leonardo Ricci, Luigi Bubacco, Mauro Dalla Serra,