| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797336 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 8 Pages |
Abstract
⺠This study was aimed to examine the antifungal activity of DDDC9G. ⺠DDDC9G showed potent antifungal activities with almost no hemolytic effect. ⺠We investigated the mode of action(s) involved in this effect using Candida albicans. ⺠DDDC9G exerted the activity on the fungal plasma membrane. ⺠The cause of the membrane damages was pore formation in the plasma membrane.
Keywords
FITC3,3′-dipropylthiacarbocyaninebis-(1,3-dibutylbarbituric acid) trimethine oxonolLUVsFITC-dextranDPHCLSIGUVMIC1,6-diphenyl-1,3,5-hexatriene3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromideDiBAC4(3)DiSC3(5)MTTAntifungal effectIndium tin oxideITOlarge unilamellar vesiclesAntifungal compoundMinimum inhibitory concentrationPlasma membraneGiant unilamellar vesiclephosphatidylinositolphosphatidylcholinephosphatidylethanolaminefluorescein isothiocyanateMethanolClinical and Laboratory Standards InstituteMeOHAntifungal mechanismforward scatterside scatter
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Authors
Hyemin Choi, Jaeyong Cho, Qinglong Jin, Eun-Rhan Woo, Dong Gun Lee,