| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797407 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 8 Pages |
Abstract
⺠Cx43 downregulates in wound edge keratinocytes and fibroblasts as they become migratory. ⺠Cx43 upregulates in blood vessels around a site of injury as they become inflamed and leaky. ⺠Actively reducing Cx43 in a wound speeds keratinocyte and fibroblast migration and healing whilst reducing inflammation. ⺠Preventing abnormal expression of Cx43 in the STZ diabetic rat wound edge keratinocytes rescues wound healing rates. ⺠Application of Cx43 antisense to venous leg ulcers significantly promotes their healing.
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Authors
David L. Becker, Christopher Thrasivoulou, Anthony R.J. Phillips,