Article ID Journal Published Year Pages File Type
10797415 Biochimica et Biophysica Acta (BBA) - Biomembranes 2012 10 Pages PDF
Abstract
► We performed MD simulations of the Cx26 channel in different pH states. ► Cx26 has a tightly closed configuration under neutral condition, while a flexible open configuration under acidic condition. ► We provide a plausible mechanism of pH-dependent gating of hemichannel.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
pH-dependent channel gating in connexin26 hemichannels involves conformational changes in N-terminus
Authors
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