| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797418 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 14 Pages |
Abstract
⺠Membrane binding activates CCT and also locally remodels the bilayer. ⺠The CCT amphipathic helix is necessary and sufficient for lipid vesicle tubulation. ⺠Nanotubes 11-12 nm in diameter can form with a density of 1 CCT/50 lipids. ⺠Pathways for nanotube generation are variable, and depend on vesicle lipid composition. ⺠CCT tubulation efficiency scales with amphipathic helix length, not binding affinity.
Keywords
sonicated unilamellar vesiclesMLVsCCTDTTdMPCNLSLUVsCTP:phosphocholine cytidylyltransferaseSUVsmultilamellar vesiclesPOPsamphipathic helixegg sphingomyelinMembrane curvatureTemlarge unilamellar vesiclesnuclear localization sequencediacylglycerolDAGElectron microscopyTransmission electron microscopyPOPEnuclear envelope
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Authors
Svetla G. Taneva, Joseph M.C. Lee, Rosemary B. Cornell,