| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797463 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 7 Pages |
Abstract
⺠Psd1 shows lipid selectivity toward membranes containing ergosterol (as fungal membranes). ⺠Psd1 mutants His36Lys and Gly12Glu present reduced membrane binding relative to wild type. ⺠Psd1 does not interact with cholesterol-rich membranes, limiting side-effects on mammalian cells. ⺠Psd1 lipid selectivity confers it a high potential to be applied as antimycotic agent.
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Authors
Sónia Gonçalves, Alexandre Teixeira, João Abade, Luciano Neves de Medeiros, Eleonora Kurtenbach, Nuno C. Santos,