| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797486 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 5 Pages |
Abstract
⺠⺠Wild-type hNav1.5 reacts readily with MTSEA, reducing INa. ⺠The mutant hNav1.5-C373Y in the closed state does not react with MTSEA. ⺠When inactivated (fast or slow), hNav1.5-C373Y does react with MTSEA after 4 min. ⺠The isoform hNav1.4 does not show the MTSEA effect. ⺠Molecular and/ or kinetic differences between the isoforms may explain the results.
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Authors
John P. O'Reilly, Penny E. Shockett,