| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797490 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 9 Pages |
Abstract
⺠H. capsulatum expresses ergosterol-dependent and -independent membrane microdomains. ⺠Pma1p and laminin binding protein are present in ergosterol dependent microdomains. ⺠Ergosterol independent rafts present integrin-like protein and glycosphingolipids. ⺠mβCD reduces by 45% H. capsulatum infectivity of alveolar macrophages. ⺠Ergosterol restores raft organization and infectivity of mβCD treated H. capsulatum.
Keywords
HRPmonohexosylceramideGIPCTNEGSLSBHIDRMTBSTMβCDECMERGHPTLCPVDFBSAGC–MSbovine serum albuminergosterolChobrain heart infusionFAMEsphosphatidylinositolphosphatidylcholinephosphatidylethanolaminePhosphatidylserinePhospholipidphoExtracellular matrixfatty acid methyl estersmethyl-beta-cyclodextrinMHCMembrane microdomainHistoplasma capsulatumHorseradish peroxidasePolyvinylidene fluoridehigh performance thin layer chromatographygas chromatography coupled to mass spectrometryfractioncholesterolGlycosphingolipids
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Authors
Loriane Tagliari, Marcos S. Toledo, Tanil G. Lacerda, Erika Suzuki, Anita H. Straus, Helio K. Takahashi,