| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797494 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 7 Pages |
Abstract
⺠We have examined how substrate structure affects sphingomyelinase activity. ⺠We have computationally docked the substrate into the active site. ⺠2N-methylation of sphingomyelin interferes with induced fit stabilization. ⺠Head-group methyls are important for proper active site alignment. ⺠Phytosphingomyelin is a good substrate despite additional hydroxyl.
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Authors
Christian Sergelius, Sanna Niinivehmas, Terhi Maula, Mayuko Kurita, Shou Yamaguchi, Tetsuya Yamamoto, Shigeo Katsumura, Olli T. Pentikäinen, J. Peter Slotte,