Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10797512 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 7 Pages |
Abstract
⺠hOCTN1 transporter reconstituted in liposomes catalyzes acetylcholine transport. ⺠The transporter in proteoliposome has the same orientation as in cell membrane. ⺠Transport occurs as uptake or efflux from proteoliposomes (cells). ⺠Efflux is physiologically related to the non-neuronal acetylcholine system. ⺠Acetylcholine efflux is defective in the Crohn's disease associated L503F mutant.
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Authors
Lorena Pochini, Mariafrancesca Scalise, Michele Galluccio, Giovambattista Pani, Katherine A. Siminovitch, Cesare Indiveri,