| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797514 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 8 Pages |
Abstract
⺠Underinvestigated Pseudomonas-lipopeptides were screened for antibiotic activity. ⺠Lipodipeptide SB-253514 possesses significant antibacterial activity. ⺠All CLPs showed high membrane binding affinity and insertion tendency. ⺠Membrane disintegration is not key for the antibiotic mode of action. ⺠The data imply a targeted mechanism for the antimicrobial activity of SB-253514.
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Authors
Katrin Reder-Christ, Yvonne Schmidt, Marius Dörr, Hans-Georg Sahl, Michaele Josten, Jos M. Raaijmakers, Harald Gross, Gerd Bendas,