| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797522 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 8 Pages |
Abstract
⺠Tubulin inhibits PMCA activity in plasma membrane through a reversible interaction. ⺠When the enzyme is reconstituted in the presence of acidic or neutral lipids and low concentrations of tubulin, PMCA is activated. ⺠PMCA is activated independently of surrounding lipid composition at low tubulin concentrations. ⺠PMCA is activated mainly by reconstitution in acidic lipids at high tubulin concentrations. ⺠Regulation of PMCA activity by tubulin is dependent on lipid composition and tubulin concentration.
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Authors
N.E. Monesterolo, M.R. Amaiden, A.N. Campetelli, V.S. Santander, C.A. Arce, J. Pié, C.H. Casale,