| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797526 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 10 Pages |
Abstract
⺠We designed a water-soluble analog to the acetylcholine receptor α1 subunit. ⺠We determined the high-resolution structure of the water-soluble analog by NMR. ⺠The analog preserved structural features observed in homologous TM domains. ⺠Photoaffinity labeling identified a relevant anesthetic binding site. ⺠We affirm the water-solubilization method for high-resolution studies of TM proteins.
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Authors
Tanxing Cui, David Mowrey, Vasyl Bondarenko, Tommy Tillman, Dejian Ma, Elizabeth Landrum, Jose Manuel Perez-Aguilar, Jing He, Wei Wang, Jeffery G. Saven, Roderic G. Eckenhoff, Pei Tang, Yan Xu,