| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797530 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 9 Pages |
Abstract
⺠The response of individual, POPC sterol-free GUVs to nystatin was studied using phase-contrast microscopy. ⺠Three characteristic nystatin-related features are revealed: vesicle shape changes, transient tension pores and vesicle ruptures. ⺠The alteration of the area difference between lipid monolayers determines the vesicle shape changes. ⺠A two-stage model of the nystatin membrane permeabilization is explained by a single mechanism. ⺠The mutually antagonizing effects of nystatin and methanol at higher methanol volume fractions can be attributed to phospholipid interdigitation.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Luka Kristanc, SaÅ¡a Svetina, Gregor GomiÅ¡Äek,