| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797554 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 9 Pages |
Abstract
⺠Malaria parasites infect human erythrocytes. ⺠The antiplasmodial quinazoline derivative M4 was complexed with 2-hydroxypropyl-β-cyclodextrin. ⺠The complex induced in vitro morphological changes to human erythrocytes. ⺠This inclusion complex interacted with the outer monolayer of the human erythrocyte membrane. ⺠Cyclodextrin facilitated the interaction of M4 with the erythrocyte membrane.
Keywords
IUMdimyristoylphosphatidylethanolamineDMPEdMPCLaurdanRBCsHPβCD2-hydroxypropyl-β-cyclodextrinDPHdimyristoylphosphatidylcholine1,6-diphenyl-1,3,5-hexatrienelarge unilamellar vesiclesFluorescence anisotropydihydrofolate reductaseCyclodextrincyclodextrinsErythrocyte membraneGeneral polarizationLUVMalariaDrug–membrane interactionInclusion complexSEMScanning electron microscopypfdhfrCdS
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Authors
Yareli Rojas-Aguirre, Francisco Hernández-Luis, César Mendoza-MartÃnez, Carlos Patricio Sotomayor, Luis Felipe Aguilar, Fernando Villena, Ivan Castillo, David J. Hernández, Mario Suwalsky,