| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797574 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 10 Pages |
Abstract
⺠Opening of the CFTR channel pore is controlled by ATP binding and hydrolysis. ⺠The conformational changes in the pore triggered by ATP are not known. ⺠We have used site-specific modification to identify changes in pore conformation. ⺠Pharmacological or mutagenic interference with ATP hydrolysis alters modification. ⺠Our results identify the location of a gate within the pore that is opened by ATP.
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Authors
Wuyang Wang, Paul Linsdell,