| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797579 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 8 Pages |
Abstract
⺠Not all histone-derived antimicrobial peptides (HDAPs) use the same mechanism. ⺠DesHDAP1 shows proline-dependent translocation, analogous to buforin II. ⺠In DesHDAP3, proline to alanine mutation increases membrane lysis and potency. ⺠Proline promotes membrane translocation in some antimicrobial peptides. ⺠Amphipathicity, not α-helicity, determines lytic abilities of proline mutants.
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Authors
Kathryn E. Pavia, Sara A. Spinella, Donald E. Elmore,