| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797580 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 12 Pages |
Abstract
⺠Cellular internalization of S413-PV peptide depends on membrane-lipid interactions. ⺠S413-PV and a scrambled analogue differently affect lipid physical behavior. ⺠S413-PV induces bilayer destabilization in lipid models and HeLa cell membranes. ⺠S413-PV uptake may be driven by lipid domain segregation and non-lamellar phases. ⺠Our data contribute to gain insights into peptide structure-activity relationships.
Keywords
DPH-PA3-(p-(6-phenyl)-1,3,5-hexatrienyl)phenylpropionic acid1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol)1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol)SAXSDPPEPOPGDPPGDSC12-ASDOPGCPPWAXSDPPCMLV1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol)1,2-dioleoyl-sn-glycero-3-phosphoethanolamine1,2-dipalmitoyl-sn-glycero-3-phosphocholine1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolaminemultilamellar vesicleswide angle X-ray scatteringlarge unilamellar vesiclesfluorescence polarizationLUVMembrane modelElectron microscopysmall angle X-ray ScatteringCell-penetrating peptideDOPEDifferential scanning calorimetry
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Authors
Ana M.S. Cardoso, Sara Trabulo, Ana L. Cardoso, Annely Lorents, Catarina M. Morais, Paula Gomes, Cláudia Nunes, Marlene Lúcio, Salette Reis, Kärt Padari, Margus Pooga, Maria C. Pedroso de Lima, Amália S. Jurado,