| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797593 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 10 Pages |
Abstract
⺠The interaction of amyloid-beta peptide on lipid membranes was investigated. ⺠Polymer cushioned lipid bilayers used as model membranes. ⺠Neutron reflectivity showed penetration of the peptide into the membranes. ⺠AFM Force Spectroscopy showed that amyloid-beta affects mechanical stability of the membrane.
Keywords
APPAβ(1–42)Polyallylamine hydrochlorideQENSSLMPoPCPEITFADLSPBSPEMPSSPAH1-palmitoyl-2-oleoyl-phosphatidylcholinesldTrifluoroacetic acidNeutron reflectivityBeta-amyloidSANSAlzheimer's diseaseScattering length densityLipid bilayerForce spectroscopySupported lipid membranesphosphate buffer salineDynamic Light Scatteringamyloid precursor proteinPolystyrene sulfonatePolyelectrolyte multilayerUlv
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Authors
Silvia Dante, Thomas HauÃ, Roland Steitz, Claudio Canale, Norbert A. Dencher,