| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797595 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 9 Pages |
Abstract
⺠Prototypic cyclotides bind to and disrupt lipid membranes. ⺠The bracelet cyclotide cycloviolacin O2 is more potent than the Möbius kalata B1 and B2. ⺠Potency is dependent on electrostatics and on cyclotide secondary and tertiary structure. ⺠A conserved glutamic acid has a key role for PE-lipid specific extraction. ⺠A 100-fold difference in bacteria to human model membrane selectivity was observed.
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Authors
Robert Burman, Adam A. Strömstedt, Martin Malmsten, Ulf Göransson,