Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes

Article ID	Journal	Published Year	Pages	File Type
10797621	Biochimica et Biophysica Acta (BBA) - Biomembranes	2011	9 Pages	PDF

Abstract

âº Cyt c forms complexes with cardiolipin (CL) and catalyzes CL peroxidation. âº Tyrosyl radicals are reactive intermediates of cyt c/CL peroxidase. âº Tyr67 is closest to the heme-iron of cyt c. âº Tyr67 mutant displayed weakest EPR radical signals and lowest CL peroxidation. âº Tyr67 is a likely electron-donor in the oxygenase half-reaction of cyt c/CL complex.

Keywords

DTPA PBS TLCL HEPES TOCl DOPC Cyt C 1,2-dioleoyl-sn-glycero-3-phosphocholine 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid Hydrogen peroxide Tyr Tyrosine Diethylenetriaminepentaacetic acid Tyrosyl radicals cytochrome c wild type H2O2 Peroxidase Cardiolipin Guanidine hydrochloride

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes

Authors

Alexandr A. Kapralov, Naveena Yanamala, Yulia Y. Tyurina, Laura Castro, Alejandro Samhan-Arias, Yuri A. Vladimirov, Akihiro Maeda, Andrew A. Weitz, Jim Peterson, Danila Mylnikov, Verónica Demicheli, Verónica Tortora, Judith Klein-Seetharaman,