| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797624 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 11 Pages |
Abstract
⺠Synthesis of a series of degradable multivalent cationic lipids (CMVLs), 2+ to 5+ ⺠Disulfide spacer between head and tails is reductively cleaved in cytoplasm ⺠Triggered disintegration of disulfide spacers significantly reduces cytotoxicity ⺠Reductive cleavage disassembles CMVLn-DNA complexes ⺠CMVLs (3+ to 5+) transfect as efficiently as benchmark reagents
Keywords
DLSφI2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborateSAXSMembrane charge densitytert-butoxycarbonylDIEADOTAPTBTUDOPCBOCRLUDOBEtBrTFATLCGSHDTT1,2-dioleoyl-sn-glycero-3-phosphatidylcholineL/DN,N-diisopropylethylamineethidium bromideTrifluoroacetic acidNucleic AcidGene deliveryTransfection efficiencydithiothreitoldiethylazodicarboxylateNonviralCationic liposomeneutral lipidCationic lipidDEADrelative light unitsSmall-angle X-ray scatteringDynamic Light Scatteringthin-layer chromatographyGlutathione
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Authors
Rahau S. Shirazi, Kai K. Ewert, Cecilia Leal, Ramsey N. Majzoub, Nathan F. Bouxsein, Cyrus R. Safinya,