Cholesterol attenuates and prevents bilayer damage and breakdown in lipoperoxidized model membranes. A spin labeling EPR study

Article ID	Journal	Published Year	Pages	File Type
10797648	Biochimica et Biophysica Acta (BBA) - Biomembranes	2011	8 Pages	PDF

Abstract

âº 40% Cholesterol in lipoperoxidized planar membranes prevents fatty acid disorienting. âº 40% Cholesterol in oxidized phospholipid vesicles counteracts membrane breakdown. âº Cholesterol maintains bilayer ordering and preserves membrane integrity in lipoperoxidation.

Keywords

PGPC PLPC EPR (ESR)SPB MLV lyso-PC Supported planar bilayers ROS multilamellar vesicles Electron paramagnetic resonance Phospholipid bilayer phosphatidylcholine Oxidized phosphatidylcholine Lipoperoxidation SUV cholesterol small unilamellar vesicles Reactive oxygen species