The fusogenic tilted peptide (67-78) of Î±-synuclein is a cholesterol binding domain

Article ID	Journal	Published Year	Pages	File Type
10797666	Biochimica et Biophysica Acta (BBA) - Biomembranes	2011	9 Pages	PDF

Abstract

âº Î±-Synuclein interacts with lipid rafts. âº Î±-Synuclein displays two cholesterol-binding domains. âº A CRAC domain binds cholesterol with low affinity. âº A tilted peptide binds cholesterol with high affinity. âº Î±-Synuclein interacts with lipid rafts through a virus-like mechanism.

Keywords

GSL initial surface pressure πi πc tilted peptide glycosphingolipid CRAC GBM MTS SBD NAC 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium Parkinson disease Initial velocity Virus fusion Lipid raft Amyloid protein cholesterol