| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797671 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 16 Pages |
Abstract
⺠This work provides the first glimpse of ion channel clusters at the molecular level. ⺠The structures show multivalent interactions between Kir2.1 and PSD-95 that drive the self-assembly of complexes. ⺠A combination of orthogonal structural techniques allows the positioning of high-resolution structures. ⺠Consistent models for all of the components involved in the formation of the Kir2.1/PSD-95 complexes are shown.
Keywords
E. coliLCMSCTFKir2.1PDZKirSH3PSD-95SRSKv1.2PSDFSCSAXSSECMAGUKEscherichia coliSDS-PAGEcontrast transfer functionPost-synaptic densityClusterinwardly rectifying potassium channelRadius of gyrationLiquid chromatography mass spectrometrymembrane associated guanylate kinaseSynchrotron radiation sourceElectron microscopySrc homology 3Fourier shell correlationVoltage gated potassium channelsmall angle X-ray ScatteringPotassium channelSize exclusion chromatographyGuanylate kinase
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Authors
Svetlana Fomina, Tina D. Howard, Olivia K. Sleator, Marina Golovanova, Liam O'Ryan, Mark L. Leyland, J. Günter Grossmann, Richard F. Collins, Stephen M. Prince,