Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10797700 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 7 Pages |
Abstract
⺠Channel activity of Kir2 sub-family of inward rectifiers is strongly suppressed by the elevation of cellular cholesterol. ⺠The goal of this study is to find the mechanism by which cholesterol regulate the function of Kir channels. ⺠Provides first direct evidence for specific binding between cholesterol and ion channel. ⺠Cholesterol-Kir binding is required for cholesterol suppression of the channel function. ⺠There is competition between radioactive and non-radioactive cholesterol for the binding site.
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Authors
Dev K. Singh, Tzu-Pin Shentu, Decha Enkvetchakul, Irena Levitan,