| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797709 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 4 Pages |
Abstract
⺠Here we demonstrate the activation of a secretory phospholipase A2 by Hsp70 in vitro. ⺠This supports the mechanism of phospholipase A2 regulation by oligomerization-amyloid formation acting as an on-off switch for enzyme activity. ⺠The activation reported here requires ATP and Mg2+, thus demonstrating that catalytic activity of HSp70 is involved. ⺠This mechanism may well be involved in the activation of other membrane associated enzymes, such as sphingomyelinase.
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Authors
Ajay K. Mahalka, Christian Code, Behnam Rezaijahromi, Thomas Kirkegaard, Marja Jäättelä, Paavo K.J. Kinnunen,