Identification of a novel endoplasmic reticulum export motif within the eighth α-helical domain (α-H8) of the human prostacyclin receptor

► Identification of a novel ER export motif in the human prostacyclin receptor (hIP). ► Lys & Arg in the α-helical 8 domain of the hIP are critical for the ER export motif. ► The ER export motif may be defined as K/R(X)4K/R(X)K/R, where X is any amino acid. ► The ER export motif is evolutionary conserved in the IPs from mouse to man.