| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797790 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 6 Pages |
Abstract
⺠Acyl chain-hydroxylated sphingomyelins (SM) exist in specialized tissues and cells, and their biophysical and sterol-interacting properties were examined. ⺠It was clearly observed that 2-hydroxylation stabilized SM interactions, whereas 3-hydroxylation destabilized, irrespective of chain length. ⺠Sterol interaction with both 2- and 3-hydroxylated SM analogs was attenuated compared to nonhydroxylated SM. ⺠We conclude that hydroxylation in the SM interfacial region markedly affects intermolecular interactions and SM/sterol association.
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Authors
Oscar Ekholm, Shishir Jaikishan, Max Lönnfors, Thomas K.M. Nyholm, J. Peter Slotte,