| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797798 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 13 Pages |
Abstract
⺠Myelin basic protein (MBP) binds microtubules (MTs) to lipid vesicles in vitro. ⺠Phosphorylation and Arg deimination decrease MBP-mediated tethering of MTs to membranes. ⺠MBP binds actin microfilaments (MFs) to MTs in vitro. ⺠MBP colocalizes with MFs and MTs in processes of cultured oligodendrocytes. ⺠MBP may act as a membrane and cytoskeletal scaffolding protein in vivo.
Keywords
LUVsMARCKSOLSRFPbc1GFPMBPMAPKmyristoylated alanine-rich C kinase substrateOligodendrocyteTemlarge unilamellar vesiclesCAMCitrullinephosphatidylcholinephosphatidylglycerolLiposomeTransmission electron microscopymapgreen fluorescent proteinred fluorescent proteinmicrotubule-associated proteinIntrinsically disordered proteinMyelin basic proteinmitogen-activated protein kinasePolyanionCytoskeletonCalmodulinoligodendrocytes
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Authors
Joan M. Boggs, Godha Rangaraj, Yew-Meng Heng, Yuanfang Liu, George Harauz,