| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797827 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 12 Pages |
Abstract
⺠Misfolded proteins of the secretory pathway are degraded by cytosolic proteasomes. ⺠Proteolysis of such molecules is preceded by their removal from the endoplasmic reticulum (ER). ⺠Key players in this process are multimeric ubiquitin ligases that are integrated into the ER membrane. ⺠These ligase complexes partake in the selection and polyubiquitylation of substrates and may also contribute to the formation of dynamic channels for protein export.
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Authors
Katrin Bagola, Martin Mehnert, Ernst Jarosch, Thomas Sommer,