Article ID Journal Published Year Pages File Type
10797827 Biochimica et Biophysica Acta (BBA) - Biomembranes 2011 12 Pages PDF
Abstract
► Misfolded proteins of the secretory pathway are degraded by cytosolic proteasomes. ► Proteolysis of such molecules is preceded by their removal from the endoplasmic reticulum (ER). ► Key players in this process are multimeric ubiquitin ligases that are integrated into the ER membrane. ► These ligase complexes partake in the selection and polyubiquitylation of substrates and may also contribute to the formation of dynamic channels for protein export.
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