| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797849 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 9 Pages |
Abstract
⺠We investigate fluid phase coexistence effects on the membrane-restructuring properties of two HIV MPER-derived peptides. ⺠For NpreTM, fluid phase coexistence elicited vesicle fusion and “graded” membrane permeabilization. ⺠For CpreTM, fluid phase coexistence enhanced “all-or-none” leakage but did not promote fusion. ⺠Confocal microscopy of single vesicles revealed the preference of both peptides for liquid-disordered domains. ⺠We infer that MPER crowding into fluid nanodomains may boost its membrane-restructuring activity during HIV fusion.
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Authors
Beatriz Apellániz, Ana GarcÃa-Sáez, Shlomo Nir, José L. Nieva,