| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797892 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 7 Pages |
Abstract
⺠Parasporin-4 (PS4) is a cytotoxic protein produced by Bacillus thuringiensis strain. ⺠PS4 exhibits specific cytotoxicity against human cancer cell lines, but not against normal tissue cells. ⺠PS4 induces plasma membrane damage to the PS4-susceptible cells. ⺠PS4 aggregates into oligomers only on the plasma membrane of PS4-susceptible cells. ⺠PS4 is a unique β-pore-forming toxin with a cholesterol-independent activity.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Kuniyo Inouye, Eiichi Mizuki,