| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797909 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 7 Pages |
Abstract
⺠More hydrophobic blockers have higher affinity hERG channel blockade. ⺠Hydrophobic blockers permeate the membrane to access the high-affinity internal binding site. ⺠Cation-Ï interactions or size effects are not a deterministic factor for blockade in the internal site.
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Authors
Kee-Hyun Choi, Chiman Song, Dongyun Shin, Sungnam Park,