| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797922 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 7 Pages |
Abstract
âºLipid microarrays were successfully used to model small molecule-membrane binding. ⺠Merocyanine 540 binding to lipid microarrays was measured using fluorescence microscopy. ⺠The impact of cholesterol on dye binding was dependent on the primary lipid component. ⺠Negatively charged lipids electrostacially repel the monomeric form of the dye from fluid phase bilayers.
Keywords
PBSPoPCDSPCdMPCDPPCCFMDOPSDOPCMerocyanine 540PDMSSOPC1-Stearoyl-2-Oleoyl-sn-Glycero-3-Phosphocholine1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine1,2-dimyristoyl-sn-glycero-3-phosphocholine1,2-dioleoyl-sn-glycero-3-phosphocholine1,2-dipalmitoyl-sn-glycero-3-phosphocholine1,2-distearoyl-sn-glycero-3-phosphocholineBSAMC540bovine serum albuminChoLipid bilayerMicroarrayphosphatidylcholinel.c.SUVLiquid-crystallinePhosphate-buffered salineFluorescence microscopypoly(dimethylsiloxane)cholesterolSmall unilamellar vesicle
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Authors
Kathryn A. Smith, John C. Conboy,