| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797950 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 11 Pages |
Abstract
⺠Valsartan, an antihypertensive drug with high affinity to the AT1 receptor. ⺠A combination of DSC, Raman spectroscopy and SAXS/WAXS is applied. ⺠Interactions of valsartan (0 to 20 mol%) with a model membrane system are presented. ⺠The localization of the drug molecule in the membranes induces lipid interdigitation. ⺠Valsartans' thermal and structural effects are illustrated on a molecular level.
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Authors
C. Potamitis, P. Chatzigeorgiou, E. Siapi, K. Viras, T. Mavromoustakos, A. Hodzic, G. Pabst, F. Cacho-Nerin, P. Laggner, M. Rappolt,