| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797960 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 18 Pages |
Abstract
⺠Biophysical approaches can be used to strengthen functional and structural information of SGLT1. ⺠Direct evidence of the initial D-glucose-binding site requiring the presence of sodium. ⺠Large extracellular loops of SGLT1 act as the vestibule for substrate binding. ⺠Loop 13 of SGLT1 localizes extracellularly. Loop 13 is involved in the binding of phlorizin to SGLT1.
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Authors
Navneet K. Tyagi, Theeraporn Puntheeranurak, Mobeen Raja, Azad Kumar, Barbara Wimmer, Isabel Neundlinger, Hermann Gruber, Peter Hinterdorfer, Rolf K.H. Kinne,