| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10798005 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 8 Pages |
Abstract
⺠Liposomal DHA increases the fluidity of cell membranes. ⺠DHA enhances non-amyloidogenic processing of APP. ⺠Enhanced secretion of sAPPα is associated with autocrine protection against apoptosis induced by ER Ca2+ store depletion. ⺠sAPPα-dependent cytoprotection relies on activation of the anti-apoptotic PI3K/Akt pathway and inhibition of the stress-triggered JNK signaling pathway.
Keywords
MLVCTFMMPneuroprotectin D1DMEMJnkNPD1Docosanoic acidAPPTBSBSAc-Jun N-terminal kinaseDulbecco's modified Eagle's mediummultilamellar vesiclesADAMAdenosine-triphosphateATPbovine serum albumindocosahexaenoic acidOmega-3 fatty acidsPolyunsaturated fatty acidPUFAAlzheimer's diseasea disintegrin and metalloproteaseTris-buffered salineApoptosisDHAsarco/endoplasmic reticulum Ca2+-ATPaseMembrane fluidityStress signalingC-terminal fragmentSERCALiposomesMitochondrial membrane potentialamyloid precursor protein
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Authors
Gunter P. Eckert, Steffi Chang, Janett Eckmann, Ekaterini Copanaki, Stephanie Hagl, Uwe Hener, Walter E. Müller, Donat Kögel,