Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10798923 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2016 | 10 Pages |
Abstract
Many metazoan cell types differentially express multiple non-allelic amino acid sequence variants of histone H1. Although early work revealed that H1 variants, collectively, are phosphorylated during interphase and mitosis, differences between individual H1 variants in the sites they possess for mitotic and interphase phosphorylation have been elucidated only relatively recently. Here, we review current knowledge on the regulation and function of interphase H1 phosphorylation, with a particular emphasis on how differences in interphase phosphorylation among the H1 variants of mammalian cells may enable them to have differential effects on transcription and other chromatin processes. This article is part of a Special Issue entitled: Histone H1, edited by Dr. Albert Jordan.
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Authors
Ruiqi Liao, Craig A. Mizzen,