Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10798937 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2016 | 15 Pages |
Abstract
While long non-coding RNAs play key roles in disease and development, few structural studies have been performed to date for this emerging class of RNAs. Previous structural studies are reviewed, and a pipeline is presented to determine secondary structures of long non-coding RNAs. Similar to riboswitches, experimentally determined secondary structures of long non-coding RNAs for one species, may be used to improve sequence/structure alignments for other species. As riboswitches have been classified according to their secondary structure, a similar scheme could be used to classify long non-coding RNAs. This article is part of a Special Issue titled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.
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Authors
Karissa Y. Sanbonmatsu,