Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10799012 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2015 | 6 Pages |
Abstract
A multitude of post-translational modifications take place on histones, one of the best studied being acetylation on lysine residues, which is generally associated with gene activation. During the last decades, several so-called co-repressor protein complexes that carry out the reverse process, histone deacetylation, have been identified and characterized, such as the Sin3, N-CoR/SMRT and NuRD complexes. Although a repressive role for these complexes in regulating gene expression is well established, accumulating evidence also points to a role in gene activation. Here, we argue that integration of various state-of-the-art technologies, addressing different aspects of transcriptional regulation, is essential to unravel this apparent biological versatility of 'co-repressor' complexes.
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Authors
H. Irem Baymaz, Ino D. Karemaker, Michiel Vermeulen,