Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10799051 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2014 | 13 Pages |
Abstract
The spatial organization of the nucleus results in a compartmentalized structure that affects all aspects of nuclear function. This compartmentalization involves genome organization as well as the formation of nuclear bodies and plays a role in many functions, including gene regulation, genome stability, replication, and RNA processing. Here we review the recent findings associated with the spatial organization of the nucleus and reveal that a common theme for nuclear proteins is their ability to participate in a variety of functions and pathways. We consider this multiplicity of function in terms of Crowdsourcing, a recent phenomenon in the world of information technology, and suggest that this model provides a novel way to synthesize the many intersections between nuclear organization and function. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development.
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Authors
Ashley M. Wood, Arturo G. Garza-Gongora, Steven T. Kosak,