Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10799052 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2014 | 12 Pages |
Abstract
Cohesins are conserved and essential Structural Maintenance of Chromosomes (SMC) protein-containing complexes that physically interact with chromatin and modulate higher-order chromatin organization. Cohesins mediate sister chromatid cohesion and cellular long-distance chromatin interactions affecting genome maintenance and gene expression. Discoveries of mutations in cohesin's subunits and its regulator proteins in human developmental disorders, so-called “cohesinopathies,” reveal crucial roles for cohesins in development and cellular growth and differentiation. In this review, we discuss the latest findings concerning cohesin's functions in higher-order chromatin architecture organization and gene regulation and new insight gained from studies of cohesinopathies. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development.
Keywords
CTCFH3K9mechromatin interaction analysis by paired-end tag sequencingH4K20me3rRNAATR-XChIA-PETRNAPIICdLSeRNAsmESCsenhancer RNAsH3K27me3ncRNALCRH3K9me3RBSARSIPSCsRNA polymerase IIRibosomal RNANon-coding RNARNA polymerase IIIchromatin immunoprecipitationMouse embryonic stem cellsCornelia de Lange SyndromeDNA double-strand breakchromosome conformation captureCCCTC-binding factorautonomously replicating sequencelocus control regionHomologous recombinationCHiPEstrogen receptor
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Authors
Alexander R. Jr., Yen-Yun Chen, Kyoko Yokomori,