Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10799053 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2014 | 12 Pages |
Abstract
The control of complex, developmentally regulated loci and partitioning of the genome into active and silent domains is in part accomplished through the activity of DNA-protein complexes termed chromatin insulators. Together, the multiple, well-studied classes of insulators in Drosophila melanogaster appear to be generally functionally conserved. In this review, we discuss recent genomic-scale experiments and attempt to reconcile these newer findings in the context of previously defined insulator characteristics based on classical genetic analyses and transgenic approaches. Finally, we discuss the emerging understanding of mechanisms of chromatin insulator regulation. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development.
Keywords
PcGIABTopoisomerase IICTCFBX-CTrxGMCPDREFpiRNAncRNABTBGAGA factorSu(Hw)CP190GAFSteroid receptor RNA activatorTSSORCSUMOANT-CUTRBithorax complexSCsMARPTSRNA interferenceRNAinoncoding RNAArgonaute 2ElbaAgo2chromatin immunoprecipitationTopo IISraCNStranscription start siteNuclear organizationcentral nervous systemSHEPAbdominal-Bchromosome conformation captureCCCTC-binding factorInsulatorAbd-BFabpreLADAntennapedia complexmatrix attachment regionuntranslated regionDrosophilaorigin recognition complexCHiPChromatinsmall ubiquitin-like modifierpiwi-interacting RNAtrithorax grouppolycomb group
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Leah H. Matzat, Elissa P. Lei,