Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10799065 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2015 | 12 Pages |
Abstract
Knockout/knockdown of each type of D has provided strong evidence for their implication in the control of important developmental processes and several D expression patterns and functions have been conserved throughout vertebrate evolution. Knockout/knockdown of the inactivating D3 enzyme indicates that a premature switch from unliganded to liganded TR action is often more detrimental than a delayed one. The majority of ontogenetic studies on TH transporter distribution and function have focused on brain development, showing variable impact of knockout/knockdown depending on the species. Future research in different models using conditional silencing will hopefully further improve our understanding on how TH transporters, Ds and TRs cooperate to regulate TR-mediated impact on vertebrate development. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
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Authors
Veerle M. Darras, Anne M. Houbrechts, Stijn L.J. Van Herck,