Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10799149 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2014 | 5 Pages |
Abstract
Transcription regulation depends on interactions between repressor or activator proteins with promoter sequences, while post-transcriptional regulation typically relies on microRNA (miRNA) interaction with sequences in 5â² and 3â²-Untranslated regions (UTRs) of messenger RNA (mRNA). However, several pieces of evidence suggest that miRNA:Argonaute (AGO) complexes may also suppress transcription through RNA interference (RNAi) components and epigenetic mechanisms. However, recent observations suggest that miRNA-induced transcriptional silencing could be exerted by an unknown mechanism independent of chromatin modifiers. The RNA-DNA
- DNA triplex structure has emerged as an important RNA tertiary motif in which successive non-canonical base pairs form between a DNA-DNA duplex and a third strand. Frequently, promoters have Purine (PU)-rich tracts, and some Triplex-forming oligonucleotides (TFOs) targeting these regulatory regions have been shown to inhibit transcription selectively. Here, we summarize observations suggesting that miRNAs exert regulation over promoter regions through miRNA-DNA
- DNA triplex structure formation stabilized by AGO proteins which represents a plausible model of RNA-mediated Transcriptional gene silencing (TGS).
- DNA triplex structure has emerged as an important RNA tertiary motif in which successive non-canonical base pairs form between a DNA-DNA duplex and a third strand. Frequently, promoters have Purine (PU)-rich tracts, and some Triplex-forming oligonucleotides (TFOs) targeting these regulatory regions have been shown to inhibit transcription selectively. Here, we summarize observations suggesting that miRNAs exert regulation over promoter regions through miRNA-DNA
- DNA triplex structure formation stabilized by AGO proteins which represents a plausible model of RNA-mediated Transcriptional gene silencing (TGS).
Keywords
HmglncRNAds-RNAssRNATFMSpiRNAParnaTFOpRNAhnRNPdhfrdouble-stranded DNAds-DNAlong non-coding RNARNA interferenceSmall interfering RNAsingle-stranded RNAdouble-stranded RNARNAisiRNATGsArgonauteTriplex-forming oligonucleotidechromatin immunoprecipitationTranscriptional regulationtranscriptional gene silencingRISCdihydrofolate reductaseTranscriptional factorRNA-Induced Silencing ComplexMicroRNAMiRNAAGOCHiPhigh mobility group
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Authors
Julia D. Toscano-Garibay, Guillermo Aquino-Jarquin,