| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10799228 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2013 | 5 Pages |
Abstract
Upon its activation, ATAD2 through its interaction with defined transcription factors, initiates a loop of transcriptional stimulation of target genes, including ATAD2 itself, leading to enhanced cell proliferation and resistance to apoptosis in an ATAD2-dependent manner. Approaches aiming at neutralizing ATAD2 activity in cancer, including the use of small molecule inhibitors of its two “druggable” domains, AAA ATPase and bromodomain, could become part of a promising anti-cancer strategy.
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Authors
Fayçal Boussouar, Mahya Jamshidikia, Yuichi Morozumi, Sophie Rousseaux, Saadi Khochbin,